Our results suggest that unlike the composition of module, which exhibits a great difference between human and mouse, the functional organization of the corresponding modules may evolve in a more conservative manner.
Overall, our results implied that unlike the composition of module which exhibited a great divergence between the human and mouse genomes, the functional organization of the modules may evolve in a more conservative manner.
Here, a double mutation replacing the wild-type Glu,Tyr to Tyr,Asn on TEM1 (res id 104,105) caused a major backbone structural rearrangement of BLIP, changing the composition of two modules but not of other modules within the interface.
Hierarchical partitioning of the hepShReD model yielded 2,098 modules, each of which comprised a subset of the original 1,418 intracellular reactions in the root module (see Additional file 1: 'ShReD_Module_Partition' for partition linkage by ID, and Sheet: 'Modules' for reaction composition of each module).
A graphical user interface (GUI) can facilitate and speed the establishment of the network topology and the composition of basic modules.
At the heart of SoftIAM is the Bespoke Framework Generator (BFG) which enables flexibility in the assembly and composition of individual modules from a pool to form coupled models within CIAS, and flexibility in their deployment onto the available software and hardware resources.
This would imply that the motif composition of transcriptional modules is quite important in Plasmodium.
Taken together, the results suggested that the composition of the modules diverged extensively between the two species.
The composition of those modules followed the genus-genus associations observed at population level (Artibeus-Ficus, Carollia-Piper, and Sturnira-Solanum), although a few of those plant genera were dispersed also by other bats.
