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For testing whether change in the number of protective factors over time was related to change in health, we used the difference between the two protective composites (Time 2 level minus Time 1 level) as a predictor, while adjusting for the composite score at Time 1, functional health at Time 1, and covariates.
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The data were collected during an 11-year period (2000 2010) with 8-day composite time steps.
Neither the Skip30, nor the composite time series seem to match the ground truth (Figure 10).
This is a composite time that includes two successive distinct periods, namely Ld and Lm.
The primary endpoint was a novel score: the composite time to complete organ failure resolution.
Figure 1 is a composite time profile of thalamic perfusion of the study groups.
The primary end-point of RESOLVE was a prospectively defined Composite Time to Complete Organ Failure Resolution score.
This study introduced the composite time trade-off, a newly developed TTO approach allowing for a more consistent elicitation of negative values.
The primary endpoint was a composite time to first recurrence of atrial fibrillation or premature discontinuation of the study drug because of intolerance or lack of efficacy.
At the end of the defined follow-up period, there was no significant difference between the two groups in Composite Time to Complete Organ Failure Resolution score.
This study was designed to test the feasibility and face validity of the composite time trade-off (composite TTO), a new approach to TTO allowing for a more consistent elicitation of negative health state values.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com