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Through their incorporation as monodisperse segments into synthetic polymers we learned in recent years how to program the structure formation of polymers, to adjust and exploit interactions in such polymers, to control inorganic organic interfaces in fiber composites and induce structure in biomacromolecules like DNA for biomedical applications.
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A NPCC network structure was believed to be formed in the composites and induced these pseudo-solid-like rheological behaviors.
The study of cell-scaffold or growth factor-scaffold composites in vitro and induced tissue and organ regeneration in vivo have been advanced by the development and extensive use three-dimensional porous biomaterials scaffold.
However, numerous studies indicated that various components of the resin composites, like BisGMA, UDMA, and TEGDMA, may be released from composite into the oral environment and induced a variety of adverse biologic effects (Geurtsen 1998; Bouillaguet 2004).
Therefore, it is very important to be able to provide the appropriate nanoparticle composite to induce and enhance the differentiation of ASCs into osteogenic lineage.
Preliminary in vitro study indicated enhanced ability of the composites to induce the formation of bone-like apatite on their surfaces.
The ability of the composites to induce precipitation of hydroxyapatite was positively evaluated by means of immersion in simulated body fluid and the best results were achieved with high glass amounts (50 wt/wtPCL%).
Furthermore, the MBG/PLLA composites could induce apatite formation on their surfaces after soaked into simulated body fluid (SBF), indicating good bioactivity.
Thermal stresses in metal matrix composites (MMC) can induce plastic deformation and damage accumulation in the region close to the reinforcements.
The effectiveness of the composite microfibers to induce and modulate osteoblastic differentiation in three-dimensional (3D) scaffolds without altering the viability and morphological characteristics of the cells was investigated.
nHA and nHA PLGA composites successfully induced osteogenic differentiation for hMSCs without the addition of osteogenic factors, achieving osteogenic differentiation comparable to that of directly adding BMP-7-derived short peptide (DIF-7c) into the culture medium.
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