This is apparent from the large number of trials including neonatal morbidity composite outcomes, each of which varies in composition.
Validated composite outcomes after complicated cardiac surgery are poorly established.
Current cardiovascular randomized trials typically use composite outcomes.
The data used for the composite outcomes of organ dysfunction and shock were extracted in a similar manner.
Composite outcomes are generally also not preferred but accepted if clinical trials reporting single outcomes are not available.
Composite outcomes are included in the benefit assessment only if all components are patient-relevant endpoints and also reported separately (Section 7.1.5 IQWiG GM 4.0).
Within the 7 days of RRT Nurses visit, overall ICU admission, mortality, and the composite outcomes were 231 (20.4 %), 106 (9.3 %), and 310 (27.3 %) respectively.
This is a well-recognized advantage of composite outcomes, but their use relies on the underlying assumption that patients will attach similar importance to each component [5].
Weighting composite outcomes according to severity or importance to patients has been suggested to deal with this issue[8], [12] [14].
Only seven trials reported neonatal composite outcomes.
We therefore assessed the composite outcomes.
