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PVD was selected as the discriminator as it is a composite marker composed of both vessel density and flow data.
Even so, each component of such a composite marker must be individually studied and assessed for potential inclusion in the model.
Therefore, many researchers have increased interest in a composite marker of stress that may represent, in a more comprehensive manner, the degree of physical stress experienced by an athlete or exercising individual.
Indeed plasma HIV-RNA is a composite marker reflecting viral fitness, replicative capacity and host control, while intracellular HIV-DNA levels reflect the establishment of HIV reservoirs and, thereof, the effect of numerous host proteins that may interact with the intracellular viral lifecycle [10].
In this process, we found that, in addition to a composite marker of hemolysis, circulating angiogenic and inflammatory markers were associated with elevated tricuspid regurgitation velocity but not with elevated mitral valve E/Etdi ratio in children and adolescents with sickle cell disease.
This paper reports that a composite marker can detect excessive mortality in a given area.
Similar(42)
Genotype data for the composite markers of the three different SNP panels was downloaded from the HapMap website (http://hapmap.ncbi.nlm.nih.gov/).nih.gov/
We also used these data to conduct analyses of marker panels (a named group of markers) and composite markers (which include a specific classification or combination rule) as well as to explore the effect of stratifying analyses by histological type.
In recent years, the field of biomarker discovery has gradually shifted from the aim of finding a single perfect surrogate marker to the construction of composite markers with higher performance, taking advantage of technologies allowing unbiased screening, including microarray analyses.
Sensitivities and specificities with precise 95% confidence intervals (CIs) were calculated for all single and composite markers [ 27].
The reader can, however, compile such composite markers and assess their usefulness following the criteria set out below.
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