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Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is associated with oxidative stress [15] and the accumulation of two characteristic pathologies, neurofibrillary tangles, composed primarily of hyperphosphorylated aggregates of tau [16], and amyloid plaques, largely composed of aggregated Aß [17].
As displayed in Fig. 1a, the as-prepared samples are composed of aggregated particles.
The shell of the hollow spheres exhibited porous structure composed of aggregated Fe3O4 nanoparticles.
However, these large-sized particles are mainly composed of aggregated nanosized particles held together by van der Waals attraction.
Porous spherical Mn3O4 particles, composed of aggregated crystallites, can be obtained from as-prepared spherical β-MnOOH.
The biofilms were composed of aggregated cocci, and fibriform extracellular matrix-like structures could be partially observed (Figure 3, Additional file 1: Figure S1).
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Domain 4 introduces a SERS layer which is composed of localized aggregated Ag nanoparticles.
Senile plaques seen in the brains of AD patients are mainly composed of the aggregated and accumulated Aβs.
This is consistent with the fact that plaques are composed of extracellular aggregated A β, while DPP10789, according to our studies, is distributed intracellularly or in the membrane [ 26, 27].
Although silk solutions with different concentrations could transform into hydrogels at different temperatures if enough time was provided for the self-assembly process from random coil to silk II (β sheet) structure, the hydrogels composed of the aggregated silk nanoparticles did not exhibit flow.
These Lewy bodies are composed of protofibrils of aggregated α-synuclein [ 69].
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