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The presenilins were the first γ-secretase components to be discovered and their subcellular localization has been determined in brain [14], [15], [16], [17], [18], [19].
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Clearly, the vertebrate Shh pathway is complex, and our incomplete understanding of the processing and regulation of intermediate steps suggests that additional components remain to be discovered.
Rather it suggests that cis-elements alone are insufficient to explain the variation in cycling expression on a genome wide scale and that additional regulatory components remain to be discovered.
How L. waltii compensates for the loss of this crucial 60S ribosome component remains to be discovered.
Food is also the best source of vitamins because it comes along with fiber, which limits the absorption of cholesterol, and with beneficial antioxidants and thousands of components whose values have yet to be discovered.
This suggests that many important components of this aGRN remain to be discovered.
However, our work strongly suggests that additional components and circuits are still to be discovered, and these may render the root SCN robust in the face of transient perturbations as well as some genetic mutations.
However, most of the components that transduce stress signals remain to be discovered and elucidated.
Considering that two thirds of the regulated genes identified through this work encode proteins of unknown function, many additional components of the stress response remain to be discovered.
If this model is correct, effector proteins should be recruited and lost from the immune system at a relatively high frequency, which implies that novel components of the immune system remain to be discovered in species of Drosophila distantly related to D. melanogaster.
This component, if it exists in brown algae, remains to be discovered.
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