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The immunohistochemical evidence of tumour-associated factor H/FHL-1 suggested that the ovarian tumour cells could carry surface components that bind factor H and/or FHL-1, proteins which both have binding sites for glycosaminoglycans and other polyanions.
Peptide nucleic acids (PNAs) are one of the synthetic components that bind to single strand DNA and RNA.
Approaches for engineering vectors increasingly include bioactive components that bind cellular receptors, disrupt membranes, or enhance nuclear transport.
Commonly, the agarose beads are coupled with protein A or G, both of which are bacterial cell wall components that bind to the constant region of the heavy chain of antibodies.
Ficolins are innate immune components that bind to PAMPs and structures on apoptotic cells.
Although most components that bind to pre-mRNPs/mRNPs are not gene specific, there are exceptions.
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B-cell anergy is thought to result from chronic antigen-receptor occupancy (Gauld et al., 2005), which could occur in the presence of self-components that bind low-affinity B-cell antigen receptors.
This report describes B. pertussis FbpABp as the first known example of a promiscuous periplasmic iron transport component that binds both unchelated iron and ferric siderophores and thus may act as a nodal point in non-heme Bordetella iron transport.
We have uncovered that beyond its well-known role as a p53 downstream checkpoint component that binds CDK2 and halts cell cycle progression, p21 can directly bind to NF-YA on the PLK1 promoter and actively suppress PLK1 transcription to inhibit mitotic entry and prevent mitotic catastrophe.
Since there is only a small number of ligands that can bind to the same protein, this limits the number of identical high-abundant protein components that can bind to the bead-bound library.
Which are the components that directly bind CenH3-nucleosomes?
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