It is on every leader's lips, the key component of "the compromise" required in the leaked details of John Kerry's "framework" for peace; a commonplace at every western diplomatic closed-door roundtable, which includes the quiet complicity of every Arab regime.
Originally, the certification process would include labeling chocolate products "Child Labor Free," but the labeling component was removed as part of the compromise.
The consequent loss of sulphated glycosaminoglycans, which are intrinsic components of the aggrecan molecule, compromises both the functional and structural integrity of the cartilage matrix and ultimately renders the tissue incapable of resisting the compressive loads applied during joint articulation.
The significance of the process is underscored by observations that even relatively small perturbations to the assembly process, such as mutations in nonessential components of the BAM complex, compromises the barrier function of the outer membrane leaving mutant bacteria hypersensitive to antibiotics.
Indeed, the effects of recent trauma, thoracic surgery, or prior radiation therapy alter components of the mediastinal silhouette and compromise the utility of the VPW [ 18, 19].
The two pronged inhibition of the ETC and F0F1 ATPase is likely to contribute to the acid sensitivity of RNS-treated bacteria, since the buffering capacity associated with the F0F1 ATPase working in reverse and the proton-translocating components of the ETC will be compromised.
However, caspase-8 can also be prometastatic if other components of the apoptotic machinery are compromised.
Consistent with this, we observed that both prenatal and lactational undernutrition accelerated puberty – although only the former was accompanied by the later development of obesity and other components of metabolic compromise, as previously reported [29].
We reasoned that if this were the case, then such changes should occur already within the thermal range of embryos in which components of the mitochondrial respiratory chain are compromised.
Failure in even a single component of the joint can compromise its functionality and progressively lead to the failure of the whole organ (Fig. 1) (Lories and Luyten, 2011).
