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Results: Labeling of the main components of the basement membrane, laminin and collagen type IV, was verified within 6 hours after in vitro endothelialization.
Objectives: Matrix metalloproteinases-2 and -9 (MMP-2 and MMP-9) are proteolytic enzymes that digest collagen type IV and other components of the basement membrane.
These motifs are present in two major protein components of the basement membrane, laminin 1 (YIGSR, RYVVLPR) and collagen IV (TAGSCLRKFSTM).
Our computational approach to annotating the planarian matrisome found evidence for the presence of components of the basement membrane toolkit found in all metazoans32 and no evidence for homologs of ECM proteins considered vertebrate-specific, such as fibronectin (Fig. 1b).
The mRNA levels of some components of the basement membrane were decreased in the missense and the nonsense NBCCS pools.
Interestingly, previous studies have shown that various components of the basement membrane are expressed in the vessel lumen during tumor [31] angiogenesis and also during wound healing [4].
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JEB involves cleavage within the lamina lucida which is a component of the basement membrane [2].
It is widely expressed in many tissues and is a component of the basement membrane [73].
The regenerated structures were surrounded by laminin-1, a key component of the basement membrane that normally circumscribes the mammary gland in vivo.
Col IV is a major component of the basement membrane and has been shown to promote and regulate the formation, elongation, and stabilization of microvessels during angiogenesis [7].
Furthermore α2 is a known Rest target gene [11] and a major component of the basement membrane in the embryonic CNS that is known to be involved in NSC development [23].
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