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Our results extend these observations by implicating the substantia nigra in psychomotor components of sickness behavior mediated by inflammatory cytokines.
This inflammatory model has been shown previously to stimulate a low-grade peripheral inflammatory response with associated cognitive, behavioral, and emotional components of sickness (24,25).
Our findings provide a mechanistic neurobiological account for heterogeneous mood-related components of sickness behavior and suggest a common pathophysiological basis for MDD and sickness-associated mood change and depression.
We predicted that the central communication of peripheral inflammation is associated with pro-inflammatory cytokine release and achieved through direct modulation of interoceptive pathways engendering core cognitive and motivational components of sickness behavior, including subjective fatigue and lethargy.
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An enhanced pain sensitivity is one component of sickness behavior in experimental animals.
Background: Enhanced pain sensitivity is a component of sickness behavior in experimental animals.
Although hyperalgesia is a presumed component of sickness behavior, little experimental data exist thus far assessing effects of systemic immune activation on pain in humans.
Functional and quality-of-life outcome measures include the return-to-work component of the Sickness Impact Profile, a simple comparative global disability scale and a visual analogue pain scale.
FK565, however, but not MDP, significantly increased circulating corticosterone, which indicates that the NOD1 agonist stimulated the HPA axis, a component of the sickness response (Lenczowski et al., 1997).
To investigate their hypothesis, the authors removed the item contributing most to internal consistency (as determined using Cronbach's alpha) in a step-wise fashion from the physical component of the Sickness Impact profile, the Barthel activities of daily living scale and the psychosocial domain of the Graves' ophthalmology quality of life instrument using data from three previous studies.
The second dataset comprised the scores on the 45-item physical component of the Sickness Impact Profile (SIP) of 227 patients with myocardial infarction [ 5](on average 2 year interval between assessments), 120 patients with stroke [ 6] (3 year interval between assessments) and 141 patients scheduled for a carotid endartectomy surgical procedure [ 7] (3 months time interval).
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