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Components of longevity, he decided, seemed to be strong parents, a good education, two happy marriages, devoted children, a sense of humor, no tobacco, little alcohol, good diet, music and work.
Genetic approaches, primarily in yeast, worms, and flies, have identified several key molecular components of longevity control [2], [6], [7].
miRNAs are emerging as important components of longevity pathways.
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This hypothesis posits a general stress response induced by caloric restriction and other stresses that protects against a variety of different stresses as an important component of longevity in all eukaryotes.
Epidemiological data indicate the presence of a strong familiar component of longevity that is largely determined by genetics.
Metabolic homeostasis, which can be regulated by autophagy during chronological aging, is a key component of longevity.
Authors compared the survival functions of nonagenarians' siblings to those of their spouses to estimate the genetic component of longevity, minimizing the effects of environmental factors.
143, 144 In addition to adiponectin levels, insulin sensitivity has also been identified as an important component of longevity and healthy aging.
Finally, the paper by P. Garagnani et al. shows the most recent results on the genetic component of longevity and healthy aging suggesting they come from the interactions of three genetic systems.
In conclusion, we postulate that particular rare mtDNA mutations, present only in specific populations, might be beneficial (or detrimental) for longevity and may explain part of the genetic component of longevity in that population, similarly to what has been suggested for private nuclear DNA polymorphisms (Beekman et al., 2013).
Furthermore, the mean lifespan across all food levels were similar in all the genotypes tested, suggesting that mutations in tph-1 and daf-7 lowered the food-responsive component of longevity around a consistent, food-independent lifespan that may be specified by other environmental parameters such as temperature.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com