First, one may not expect dosage compensation in testis and the authors did notice that the key component of dosage compensation, msl-2, does not appear to function in testis.
Thus, several features of this scenario lead us to propose that postzygotic isolation between species of the melanogaster subgroup might be partly the result of an improper dosage compensation caused by Nups functional divergence as it also happens for other components of the dosage compensation complex (Rodriguez et al. 2007; Sawamura 2012).
Accordingly, research on radiation-induced apoptosis has traditionally focused on the biological effect of the total dose delivered to a given system while overlooking the individual contributions of the various components of the dosage.
Its recent evolution makes it likely that other components of mammalian dosage compensation already existed before the advent of Xist.
(4) Of the 13 mutants recovered, 4 mapped to genes encoding known components of MSL dosage compensation complex.
This strategy is a promising alternative route for identifying previously unknown components of the dosage compensation pathway and novel alleles of known MSL proteins.
Mapping and complementation analysis indicated that three mutations are unusual alleles of msl1 and one maps to mle, two critical components of the dosage compensation complex.
Of the 13 mutations isolated, 4 mapped to known components of the dosage compensation complex demonstrating the specificity of the screen design.
Consistent with this hypothesis, autosomal retrogenes are often derived from X-linked parental genes that reside close to components of the dosage compensation machinery [ 16].
We developed a new genetic strategy to identify components of the dosage compensation pathway in Drosophila using a simple dominant eye colour phenotype.
