Sentence examples for components of destruction from inspiring English sources

Moreover, LRP 5/6 phosphorylation inhibits the components of "destruction complex" such as GSK-3 β and APC [ 46].

We found APC2 is also a dynamic component of destruction complex puncta, reaching a recovery plateau of 40% and a t1/2 of 150 s; however, APC2 is not as dynamic as Axin.

Phospho-β-catenin has recently been reported in two separate complexes: one with E-cadherin and the other with components of the destruction complex [18].

If Wnts were acting through a β-catenin-dependent pathway, we would expect components of the destruction complex to be required for axon termination, and β-catenin and TCF to be instead required for axon elongation.

For the WNT/β-catenin inhibitors to block cartilage degradation effectively, they should interfere with both components of cartilage destruction.

Wnt ligands/receptors or the components of the destruction complex may be involved in the CagA-positive H. pylori-induced activation of the Wnt/β-catenin signaling pathway.

Axin (Axin1 and Axin2) is a scaffold protein that directly interacts with other core components of the destruction complex [ 129, 184, 185].

Genes encoding components of the destruction complex, for example APC or Axin, are often mutated, resulting in β-catenin accumulation in cancer samples (Jin et al, 2003; Morin et al, 1997; Polakis, 2007).

As a scaffold protein that directly interacts with other core components of the destruction complex [ 12, 129], the scaffolding function of Axin is essential in the process of β-catenin phosphorylation by GSK3 because the interaction of GSK3β with the Axin can enhance phosphorylation of β-catenin by several orders of magnitude [ 130].

In the absence of the Wnt ligand, cytoplasmic β-catenin is bound by the components of a "destruction complex" comprising Axin, kinases CK1α and GSK3, and the adenomatous polyposis coli (APC) protein, which phosphorylates β-catenin and marks it for proteosomal degradation.

A core component of the destruction complex, axin, is not present in cell protrusions with APC and is not detected at cell-cell junctions; 6. Accumulation of APC and phospho-β-catenin at the ends of cell protrusions and at the leading edge of migrating cells suggests that this population has an active role in microtubule regulation, cell-cell or cell matrix interactions.