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We also identified several proteins relevant to telomere homeostasis: the four core components of box H/ACA snoRNPs (DKC1, GAR1, NHP2 and NOP10; all part of the active telomerase RNP (Wang and Meier, 2004)) and the Ku70 Ku80 heterodimer proteins.
In particular, the core components of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), DKC1 (dyskerin), GAR1, NHP2 and NOP10, are part of the active telomerase complex, and are necessary for proper RNP assembly as well as for TERC stability (Mitchell et al, 1999; Wang and Meier, 2004).
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Add long distance runs to your routine to help improve your stamina and to condition your body for the aerobic components of boxing.
Nucleolar localization of the components of the box C/D snoRNPs would therefore depend on the biogenesis of the box C/D snoRNP complexes, which would imply nuclear export.
Depletion of the protein components of C/D box snoRNPs resulted in a marked and consistent reduction in the expression levels of nearly all transcripts annotated as C/D box snoRNAs for proteins Snu13 and Nop58.
A number of transcripts containing canonical Sm binding element sequences (Sm Y RNAs) also showed reduced expression after depletion of protein components of C/D box snoRNPs, whereas the expression of some stem-bulge RNAs (sbRNAs) was increased after depletion of the same proteins.
In comparing the ultimate stress calculated by design methods in different codes with the experimental and numerical results, it was found that for the component plates of box section members, the design methods overestimated the ultimate stress of local buckling, so that the result was not safe enough.
Sik1p (Nop56p) is a component of the box C/D snoRNP complexes that direct 2′-O-methylation of pre-rRNA during its maturation.
The i-th component of the box x = (x 1,..., x n ) is the interval x i = [ x ¯ i, x ¯ i ] and the interval extension of a set D ⊆ ℝ n is I D : = { x ∈ I ℝ n : x ¯, x ¯ ∈ D }.
The two unsupported H/ACA box snoRNAs (CeN128 and CeN85) were not only unaffected by depletion of protein components of the H/ACA box snoRNPs, but rather showed reduced expression levels after depletion of protein components of C/D box snoRNPs, supporting a recent claim that one of these (CeN128) belongs to the C/D box snoRNA sub-class [ 15].
Searching Either a device initiates a search – for example to find the current π-Box – or other components of the π-Box incorporate the search function as a subroutine for other tasks.
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