Overclocking may, however, seriously compromise system reliability in insufficiently cooled computers and generally shorten component lifespan.
Somatotropic hormones and their downstream signaling components regulate lifespan in animals (reviewed in Kenyon, 2005, 2010; Berryman et al., 2008).
Fourth, relative measures of TL (corrected for age) correlate with fitness components including lifespan (e.g. [ 11, 15, 17]).
In addition to results demonstrating its function as a pleiotropic aging gene, data from the wild suggest that mth may be an important component in lifespan evolution.
The significance of functional variation at mth is reinforced by the adaptive pattern this allelic variation exhibits among natural populations, and suggests that mth may be an important component in lifespan evolution.
A compelling argument can be made, for example, that autophagy is in an important component of lifespan regulation in all eukaryotes [ 61].
Although genotype was not a significant component of lifespan variance within the diallel, in the introgression experiment, both (C24 x Col) +/+ and (C24 x L er) +/+ lived significantly longer than their parents.
This is a major challenge because the genetic component of lifespan variation in the population at large has been estimated to be only ∼25% (10, 11) and is assumed to be determined by many, still uncharacterized, genes (12, 13).
Genetic or pharmacological intervention of their components can extend lifespan and delay age-associated dysregulation [8].
Nonetheless, the existence of a negative correlation for fitness between the sexes in O. taurus cannot be ruled out completely with our current data; the analysis of the covariance between further fitness components (e.g., lifespan, reproductive success, etc).
