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Their approach was based on the assumption that low-frequency components in gene expression data contain most biologically relevant information.
For instance, sequences coding for translation initiation factors SUI1 and for restriction modification type 1 endonucleases fall into distinct connected components in gene networks [ 6].
These proteins have been reported to be associated with fiber development, including being important components in gene regulation, in cytoskeleton and cellulose synthesis, and in proton and cation transporting [ 5, 7, 8].
Evidence for the importance of stochastic components in gene expression changes with age has been provided previously using different approaches [ 20, 54], but ours is the first direct evidence that transcriptomes of individual animals can significantly diverge as a consequence of the aging process, and not just between individual genes.
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Iterate all the gene components in the gene array; when a gene with Ensembl-ID matches a key of miRT, then the corresponding miRNA is created in the model by defining name, ID, location and other.
Analysis of the ChIP-Seq regions is now a central component in gene regulation studies.
The recognition of alternative splicing and alternative isoform expression as an important component in gene expression analysis has prompted the introduction of isoform sensitive microarray platforms.
Although the importance of stochasticity in gene expression has been anticipated more than three decades ago [ 1- 3], the existence of a strong stochastic component in gene expression has only recently been experimentally demonstrated, showing that, despite constant environmental conditions, isogenic cells do show significant fluctuations in their gene-expression levels [ 4- 10].
Over the past year, developments in our ability to monitor the organisation and dynamic properties of the components involved in gene expression have emphasised how both global nuclear architecture and chromosome structure can influence this fundamental process.
As potent regulatory components involved in gene regulation from various aspects, lncRNAs can exert their effects during tissue development and in response to external stimuli [20].
Homologous gene groups are defined as connected components in a gene graph.
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