Although the exact underlying mechanisms of DDC-induced cholangitis are unknown, increased porphyrine secretion and induction of a reactive cholangiocyte phenotype via toxic bile components are implicated in the development of the histological features in this model.
Amylin is the most abundant component of islet amyloid implicated in the development of type 2 diabetes.
Many components of the inflammatory pathway, including free radicals, cytokines, cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and vascular endothelial growth factor (VEGF) have been implicated in the development of various malignancies, including OC [ 49].
10 The BCR is a key component of normal B cell development and is also implicated in the development of the most common B cell malignancies, including diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma, and CLL.
Both miR-146a and miR-155 have also been implicated in the development of rheumatoid arthritis, possibly by regulating components of the inflammatory response [16], [17].
This effect is mediated by Hsp90 inhibition-induced HER2 degradation and, additionally, via effects on component proteins of the PI3 k-Akt pathway, p95, and HER3, all of which are implicated in the development of trastuzumab resistance [ 3, 4].
Although the immune system has been implicated in the development of MM, the scientific literature on the role and status of various immune components in this process is broad and sometimes contradictory.
Several factors have been implicated in the development of pin track sepsis [4, 21].
Anterior cruciate ligament (ACL) rupture has been implicated in the development of knee osteoarthritis (OA).
Loss of function of DNA repair genes has been implicated in the development of many types of cancer.
