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This report describes B. pertussis FbpABp as the first known example of a promiscuous periplasmic iron transport component that binds both unchelated iron and ferric siderophores and thus may act as a nodal point in non-heme Bordetella iron transport.
We have uncovered that beyond its well-known role as a p53 downstream checkpoint component that binds CDK2 and halts cell cycle progression, p21 can directly bind to NF-YA on the PLK1 promoter and actively suppress PLK1 transcription to inhibit mitotic entry and prevent mitotic catastrophe.
Mannose-binding lectin (MBL), an innate immune system component that binds to carbohydrates, activates the complement cascade and promotes destruction of microorganisms and abnormal cells.
The difference is that the component that binds calcium ions in the molluscan muscle is myosin rather than a component of the actin-containing thin filaments.
NPC1 is a transmembrane protein with a sterol-sensitive domain (Carstea et al., 1997) and NPC2 is an intralumenal component that binds cholesterol (Naureckiene et al., 2000; Soccio and Breslow, 2004).
The classical MHC I molecule mainly functions as a component that binds antigenic peptides, presenting them to the T-cell receptor to trigger the cellular immune response [3].
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The immunohistochemical evidence of tumour-associated factor H/FHL-1 suggested that the ovarian tumour cells could carry surface components that bind factor H and/or FHL-1, proteins which both have binding sites for glycosaminoglycans and other polyanions.
Approaches for engineering vectors increasingly include bioactive components that bind cellular receptors, disrupt membranes, or enhance nuclear transport.
Peptide nucleic acids (PNAs) are one of the synthetic components that bind to single strand DNA and RNA.
Commonly, the agarose beads are coupled with protein A or G, both of which are bacterial cell wall components that bind to the constant region of the heavy chain of antibodies.
Ficolins are innate immune components that bind to PAMPs and structures on apoptotic cells.
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