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Elastin is a critical biochemical and biomechanical component of vascular tissue.
Here, in a striking parallel to tumor pro-angiogenic signaling, we identify angiopoietin-2 (ANG-2) induction as an important component of vascular dysfunction during mycobacterial infection.
This technique should provide the much-needed means to allow 3-dimensional evaluation of morphology to become a routine component of vascular remodelling studies.
Vasomotor tone is currently thought to be a critical component of vascular remodeling.
SVR therefore does not reflect vascular tone, although it can be considered to be a component of vascular tone.
As the major component of vascular media, smooth muscle is the main effector of pulmonary arterial remodeling [ 41].
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The new frontier in ACS management has focussed on treatment of these components of vascular disease.
Macrophages are key components of vascular inflammation, which contributes to the development and complications of atherosclerosis.
As multifunctional components of vascular structures, endothelial (progenitor) cells have been utilized in cellular therapies and are required as an important cellular component of engineered tissue constructs and in vitro disease models.
A role for sterols as essential components of vascular patterning is evident from biosynthesis mutant phenotypes, but the molecular basis of their actions is not well understood.
However, studies comparing RHI and FMD indicate that they are measuring distinct components of vascular health.
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