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Extracellular matrix (ECM) is the non-cellular component of tissues, which not only provides biological shelter but also takes part in the cellular decisions for diverse functions.
The ECM, comprising the non-cellular component of tissues, is a signalling depot that is differentially regulated in scarring and regenerative healing.
Cells respond to a variety of stimuli present in the ECM, which compose of fibrous proteins, proteoglycans, and glycoproteins, and act as a main regulatory and structural component of tissues in vivo.
The ECM is a substantial component of tissues and thus essential for tissue function, architecture and homeostasis, yet the investigation of ECM function presents many technical challenges.
An emerging issue in the carcinogenesis field has arisen from studies that revealed that a chronic inflammatory condition predisposes the epithelial component of tissues to develop a tumour (Coussens and Werb, 2002).
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In addition, excessive activation of neutrophils is a major component of tissue damage and organ failure in sepsis [39].
Despite these considerations, it has been emphasized that the MFI only represents the convective component of tissue perfusion and oxygenation.
Pluripotent and/or multipotent stem cell-based therapeutics are a vital component of tissue engineering and regenerative medicine.
Thus, pharmacological manipulation of the signaling pathways with bioactive molecules is an important component of tissue regeneration.
A variety of biomaterials have been used to construct neural scaffolds, the main component of tissue engineered nerve graft.
Because PVD takes into account both MVD and MFI changes, it represents also the diffusive component of tissue oxygenation, resulting in a more integrative variable.
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