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Association between each module's first principal component of the expression data and clinical improvement was tested in the three cohorts.
Tomfohr et al. [28] and Bild et al. [23] used the first principal component of the expression profile of the member genes to estimate the activity of a given pathway.
Rather, it identifies and grades the magnitude of the immune component of the expression profiles.
aThe correlation coefficient was calculated from the module eigengenes (i.e., first principal component of the expression values across subjects) and phenotypic characteristics of ECs using Pearson correlation.
The third component of the expression data was dominated by the melanoma and leukemia lines' expression, explaining 5.2% of the variance.
Once modules were identified, the module eigengene (ME; i.e. the first principal component of the expression values across subjects) was calculated using all probe sets in each module.
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It is useful to have a notation for "nextand" (i.e., "not-exists-and") without assuming either that x has a free occurrence in the expressions joined, or that if it has one, then it is the last component of the expressions.
Furthermore, it identified the ranked immunological components of the expression profile of a tumor with its associated networks of interactions.
The estimated factors in the model capture components of the expression heterogeneity independent of the effects of the variable of interest.
Additionally, we calculated principal components of the expression data residualized for its first five principal components to account for unmeasured batch effects as outlined elsewhere (12).
To try to distinguish the genetic from the environmental components of the expression patterns of HERV-W gag elements, we employed cultures of human primary fibroblasts from healthy individuals and subjected them to serum deprivation.
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