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CCR5 is an essential component of the entry mechanism for HIV; if there is no entry, there is no infection and there is no risk of transmission to others.
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In this case all components of the entry are imported.
Several research groups have looked into the possibility of using RNA interference (RNAi) technology to shut down key components of the entry machinery of the virus.
Glycoprotein B (gB) is the most conserved component of the herpesvirus entry machinery and its N terminus (gB-NT) is a common neutralization target.
We concluded that components of the VACV entry fusion complex are required for entry in S2 cells.
The HIV-1 fusion peptide, comprising 15 to 20 hydrophobic residues at the N terminus of the Env-gp41 subunit, is a critical component of the virus-cell entry machinery.
Click 'Edit' on the blue component bar of the Location Entry component.
This additional force consists of compressive component arising at the entry of the contact and a vacuum one acting on the contact exit.
Each occurrence of a particular chemical component from the entry, referred to here as an 'instance', is listed in the Results Report with the 'Top Hit' component found in the CCD and the corresponding 'Match Status'.
These investigators explored the use of doxycycline-inducible shRNA expression for transient knockdown of an mRNA encoding the tight junction protein claudin-5, a component of the microneurovasculature that regulates the entry of small molecules through the blood brain barrier (BBB) and inner blood retinal barrier (iBRB) (Fig 1).
The role of STIMATE, a previously unknown component of the store-operated calcium entry complex, has now been identified and defined.
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