Progress towards the development of therapeutically effective ADCs, ITs and CFPs depends on the selection of an appropriate target and the corresponding binding component, on the efficacy of the cytotoxic payload and on the nature of the linkage between these two modalities.
Moreover, the dismantling design of the current study will allow the identification of the contribution of the behavioral activation component to the efficacy of the complete intervention program.
Second, efficacy, or a component of efficacy (response efficacy or self-efficacy) had to be manipulated.
Women's report of full disclosure of study product use and partner approval for products were significantly associated with their acceptability and consistent use; an essential component of determining the efficacy of an investigational prevention method.
These results support the notion that Hsp70 expression is a key component of the neuroprotective efficacy of KU-32.
Therefore, it comes as no surprise that one component of the therapeutic efficacy of IgG1 mAbs is immunological.
A component of the therapeutic efficacy of IgG1 mAbs is their stimulation of antibody-dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells bearing the CD16 receptor.
Each component of the primary efficacy end point was independently adjudicated by the blinded Clinical Events Committee (for clinically driven target lesion revascularization) or by the core laboratories (for restenosis).
In contrast to MEDENOX, which largely evaluated the impact of thromboprophylaxis on venographically detected and largely asymptomatic distal DVT, in PREVENT the major component of the composite efficacy outcome was asymptomatic proximal DVT assessed by systematic screening with compression ultrasound.
Secondary efficacy measures included each of the components of the primary efficacy measure, the incidence of distal DVT (alone and in combination with proximal DVT), the incidence of symptomatic DVT, the incidence of a combination of proximal DVT, non-fatal PE and death from all causes including PE, the incidence of death from all causes; incidence of documented symptomatic VTE.
