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In EUPHAS 2 registry, the cardiovascular component of SOFA represented 26.7%% of the overall score when the treatment was started.
In one study, however, all derivatives of the cardiovascular component of SOFA did better than that of MODS [ 16].
bThe baseline model was adjusted for each component of SOFA score on the day of ALI onset.
The time-varying model was adjusted for each component of SOFA score on all days in the ICU prior to the day of first event.
The neurological component of SOFA was left out because of the difficulty to assess the actual Glasgow Coma Scale in sedated patients.
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The Cox regression analysis of 28-day mortality recognized the variation between baseline and 72 h of cardiovascular and coagulation components of SOFA score as independent covariates.
Four studies (22%) evaluated individual components of SOFA [ 10, 14, 16, 21] (Table 5).
The differences between the individual components of SOFA scores are presented in Additional file 1: Table S3.
The major themes identified in the evaluation studies were investigating the performance of: single SOFA scores at admission or at a fixed time after admission; sequential measurements of SOFA (e.g. mean SOFA score); individual components of SOFA (e.g. cardiovascular component); combination of SOFA with other covariates; and temporal models using patterns discovered in the SOFA scores.
Changes in renal function (total daily urine output and renal component of the SOFA score), GCS component of the SOFA score, total SOFA score and worsening thrombocytopaenia were also independently associated with secondary outcomes (ICU, hospital and 28-day mortality).
Septic shock at the time of randomization was defined as a cardiovascular component of the SOFA score of 1, 3 or 4 [ 11].
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