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A compelling argument can be made, for example, that autophagy is in an important component of lifespan regulation in all eukaryotes [ 61].
Although genotype was not a significant component of lifespan variance within the diallel, in the introgression experiment, both (C24 x Col) +/+ and (C24 x L er) +/+ lived significantly longer than their parents.
This is a major challenge because the genetic component of lifespan variation in the population at large has been estimated to be only ∼25% (10, 11) and is assumed to be determined by many, still uncharacterized, genes (12, 13).
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Although there is only one recent report available in literature showing positive effect of amla (in form of drug) on life span and reproductive fitness of Drosophila to certain extent [ 34], it has also been earlier reported that dietary supplements of curcumin (a component of turmeric) extends lifespan of D. melanogaster [ 21].
However, the role of each nutritional component in the regulation of lifespan is not well established.
Importantly, inhibition of TOR or raptor, an essential component of TOR complex, extends lifespan dramatically.
Finally, a comprehensive audit of implementation of LIFEspan (the process evaluation component) will allow for a detailed description of the intervention received by the participants.
Because trends in lifespan variability depend on the changing distribution of mortality, sensitivity analysis offers an appealing way to quantify the influence of each component of the Siler model on lifespan variability patterns across both age and time.
Genetic components account for from 20 to 30% of lifespan, according to twin-based population studies [ 1, 2].
The autophagy gene bec-1, the homolog of mammalian beclin 1, is required for the increased lifespan of daf-2 mutant animals [ 94], suggesting that autophagy is an essential lifespan-prolonging component of the stress responses typically held in check by IIS activity.
As in humans, mutations in the Drosophila homologs of the DGC components result in muscle degeneration, mobility defects and shortening of lifespan (Shcherbata et al., 2007).
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