We found that many edible and medicinal could transform natural components of herbs; especially C. comatus could transform ginkgolide.
However, very limited information is available on how these edible and medicinal fungi transform the components of herbs.
Recent advances on the databases cataloguing chemical components of herbs and the interactions between drugs and targets have contributed to predicting the drug targets of herbs.
The exploration of the interaction between tanshinone IIA and its target proteins provides a feasible platform for studying the anticancer mechanism of active components of herbs.
In order to explore its underlying mechanism, we compared the different edible and medicinal fungi, including Lentinus edodes, Agaricus bisporus, Coprinus comatus, Ganoderma lucidum, Hericium erinaceus, Pleurotus ostreatus, Pleurotus eryngii, Boletus edulis and Cordyceps sinensis, and components of herbs, including flavonoids, terpenoids, alkaloids, anthraquinones and so on.
A screening method involving in the binding of molecules to the membranes of human red blood cells and high-performance liquid chromatography (HPLC) analysis was developed to identify the active components of herb extract [ 8].
Geniposide, the major iridoid glycoside component of Gardenia herbs, which has been recognized to have choleretic effects, is transformed to genipin in animals.
Silibinin is a major component of traditional herbs and is widely used in the treatment of hepatic diseases.
Chinese patent medicine (CPM) is an important component of Chinese herbs, and is widely accepted by the Chinese people due to the convenience of application.
Because it is a component of many herbs and spices, differences in dietary habits along with the natural variation in levels of methyl eugenol in plants (Di Cesare et al. 2003; Smith et al. 2002) makes a definitive prediction of exposure difficult.
