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There is a component of challenging madness in all this; a madness which challenges the expectation of the Major Man.
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A component of Challenge 4 of the DREAM2 competition [ 38] is predicting the connectivity of three in silico networks generated using simulations of biological interactions.
In certain situations, there's a component of challenge to this behavior.
Complex genetics, combined with the traditional classification of cardiac malformations by physiology and anatomy, have made investigation of the genetic component of CHD challenging.
Thus it is possible that not only the sampling time, but also the mode and individual components of challenge agent may influence the dynamics of cytokine regulation.
Cities face many of the same challenges, from crippling pension costs to crime to public-health issues, so a major component of the challenge is that the proposed ideas must be replicable.
However, it makes sensitivity analysis of a single study component exceptionally challenging.
Every effort was made to arrange modules so those with shared nodes and high connectivity are located in close proximity, however given the issues in depicting information on this scale, 'ideal' arrangement of components is challenging.
One component of these challenges is to attain high protein solubility (>50 mg/ml for immunoglobulins) with minimal aggregation.
The second component of the challenge to UK corporate law and regulation that the adoption of purpose poses relates to what the paper calls the legal ecology of purposeful companies.
Ownership of radio frequency "real estate" is a huge component of the challenges that both SpaceX and OneWeb face in this game.
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