Taken as a whole then, the AIL approach successfully resolved the complex Tir3 locus into three component loci, and together with Tir1 and Tir2 mapped four of the resultant five Tir loci (all except for Tir3b) to CI that are sufficiently narrow (<2 cM), to make positional cloning feasible.
A genome-wide association study examining more than 300,000 SNPs among approximately 1,500 autoantibody-positive RA cases and 1,800 controls identified a genetic variation at the TRAF1-complement component 5 locus as an important RA risk locus [ 74].
Carriers of the common allele at SNP rs10936599, near the telomerase RNA component (TERC) locus, had significantly longer telomeres.
Each two component spanin locus encodes an integral inner membrane protein (the IM spanin), and an outer membrane lipoprotein (the OM spanin); these are the functional equivalents of the lambda Rz and Rz1 proteins, respectively.
It has become a strong working hypothesis that MHC and non-MHC genetic components share loci that are common in various autoimmune diseases and in corresponding animal models [ 62].
A second component of this locus contains a smRNA signal immediately adjoining a GWAS hit.
Schemes that selected donors regardless of their family structure were superior, and the quantitative trait locus component with more loci increased the effectiveness of sorted semen.
Two factors that affected the contribution of marker-assisted selection were studied: 1) within- vs. across-family selection of donors, and 2) the number of loci in the quantitative trait locus component.
Remarkably, meningiomas developed in double-mutant mice do not show features characteristic of high-grade meningioma suggesting that loss of the p14Arf rather than the p16Ink4a component of the locus is critical for malignant transformation of meningiomas.
For example, one group also found a single major locus component, but they concluded that the inheritance pattern did not conform to inheritance patterns based on Mendelian expectations (Cox, Kramer, & Kidd, 1984).
