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Striking ethnic variation in prevalence [ 2- 6] along with familial clustering [ 7- 9] are suggestive of an important role of the genetic component in the pathogenesis of the disease.
Although the etiology of ADHD is not fully understood, a strong genetic component in the pathogenesis of the disease with an estimated heritability of 60 80% has been reported [ 1, 3].
Apart from the presence of shared environmental factors, this familial aggregation can be explained for the most part by an important hereditary component in the pathogenesis of the disease.
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There is general agreement that the etiologic key component in the pathogenesis of these metabolic diseases is insulin resistance (IR).
Multiple studies support the influence of genetic components in the pathogenesis of the disease [9, 12].
In common with obesity, there is a genetic component to the pathogenesis of the metabolic syndrome.
Although there is a genetic component in the pathogenesis of epilepsy, the molecular mechanisms of this syndrome remains poorly understood.
C-reactive protein (CRP), the prototype acute phase protein, may represent an important component in the pathogenesis of arteriosclerosis and may also be a target for drug development.
Disruption of any of these essential processes is an important component in the pathogenesis of many diseases, including cancer.
Th2-dominated inflammatory response in the airway is an integral component in the pathogenesis of allergic asthma.
Furthermore, studies of identical twins suggest a genetic component in the pathogenesis of nephropathy in T2DM, and less so in T1DM [19].
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