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Co-deposition of MnO2 and PPy has a complimentary action in which porous PPy matrix provides high active surface area for the MnO2 nanoparticles and, on the other hand, MnO2 nanoparticles nucleated over polymer chains contribute to enhanced conductivity and stability of the nanocomposite material by interlinking the PPy polymer chains.
This means that they can cooperate on the global oxidative stress generated, because they have a complimentary action.
Combination therapy optimizes the effectiveness of each treatment by their complimentary action that will eventually result in synergistic therapeutic response, while at the same time reducing toxic adverse side effects associated with high dose monotherapy [ 5, 15].
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Gastrin and G-Gly have separate but complimentary actions on cell signaling pathways and gene transcription.
They were strangers before take off and all over each other by the time we landed a lot of under-the-complimentary-blanket action happening.
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Combining treatments offers the advantage of gaining benefit from medications with different and complimentary mechanisms of action while limiting concerns regarding overuse of a single agent.
This is consistent with the observation that the effectiveness of anticancer chemotherapy may be improved when multiple drugs with complimentary mechanisms of action are used in combination.
However, a study by Ozeki et al., demonstrated complimentary but independent action of α2 integrin and MMP-3-mediated signalling cascades in driving mouse embryonic stem cell differentiation into odontoblast-like cells [ 57].
The potential complimentary mechanism of action and good tolerance profile of these two classes of agents make them attractive treatment options for combination therapy with any of the existing glucose-lowering agents, including insulin.
Levosimendan is a calcium sensitizing agent with two complimentary mechanisms of action, enhanced cardiac troponin C sensitivity to intracellular calcium and peripheral vasodilation through opening of smooth muscle ATP-dependent potassium channels, as well as some potential PDE3-I activity.
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