Due to the fact that the test is labor-intensive and technically complicated, the testing turn-around time can be as long as 6 weeks.
This can complicate the test results, and consequently increase the probability of failure.
Therefore, the addition of the intestinal phase, although possible, does not appear essential, and also complicates the test and its validation.
The inherently subjective nature of the test complicates the test interpretation task [ 7].
Several researchers have noted that possible trade-offs between size, number, and sex of offspring complicate the test of the TW hypothesis in polytocous species (Williams 1979; McGinley 1984; Gosling 1986; Carranza 2004; Servanty et al. 2007).
Typically, non-pharmacological therapies are delivered as part of a package of care rather than as a single treatment alone [ 14], further complicating the design of trials to test treatment effectiveness.
Designing a survey to detect the presence of a disease is complicated if the test used to detect the disease has non-perfect sensitivity and specificity.
The length of the tensile loading regime complicates the development of test setups that can capture the full tensile response at high strain rates.
From a clinical perspective, this naturally complicates the interpretation of tests, since "positive" findings may thus be attributed to measurement error.
Apart from five cases who died of cardiovascular diseases (3), Paget disease (1), and lung cancer (1), the other cases all died because of the condition complicating CD. *Chi test, **t test, ***Mann–Whitney test, CD = coeliac disease; CCD = complicated coeliac disease; NS = not significant.
