To complicate matters, the methodology for measuring myopia also changed over the years.
Our selections differed considerably in methodology - especially in the definitions of intervals before diagnosis, which made quantitative synthesis inappropriate, and complicated the narrative synthesis.
That complicated the issues.
The less complicated the better.
There is not a defined line of research on this subject; the studies show specific, isolated difficulties and problems, and these complicate the comparisons of methodologies and results.
However the high variability of the mtDNA CR (119 parsimony informative sites and an average of approximately 5.3 fixed positions for each cluster of sequences) complicate the set-up of the methodology.
These groups have "different outlooks, goals, methodology," which complicates the task faced by the Greek police, he said.
Vernacular German authors, Giesecke has argued, although they shared with Latin authors the same stock of knowledge about the natural world and the human body and accepted the same underlying logic, achieved the correct balance by downplaying complicated scholastic methodology while emphasizing practical applications.
Although this flexibility is an advantage for the implementation of EPODE methodology itself, it complicates the establishment of a robust evaluation framework common for all communities [ 16].
Third, detection of MUC1 and VEGF mRNA using RTQ-PCR is relatively complicated in methodology and experimental handle is time--consuming which may influence routine use in clinical practice, although RTQ-PCR is a highly sensitivity and specific analysis tool.
