The ubiquity of acrylamide in processed food has complicated studies of its potential cancer-causing affects in humans.
This apparent "redundancy" has complicated studies of mammalian serpins, as most serpin null mutations give no discernable mutant phenotype.
Large ridge motions and large seabed deformations complicate study of the seabed scouring and pipe interaction using classical Lagrangian methods.
In addition, malignancy and bone abnormalities, pain, vascular abnormalities, and in 60% of cases, learning disabilities complicate study of NF1.
Since functional redundancy with the transcription factors Atf7 and Cre-bpa (Creb5) complicates study of ATF2 function in mice (Breitwieser et al., 2007), we overexpressed a dominant negative ATF2 in hepatocytes.
Morimura et al. (2006) and Hays et al. (2005) used high concentrations (with mortality), few (and differing numbers of) animals in treated versus control groups, and differing periods of exposure (all ≤ 1 year) complicating study interpretation.
This day-time dependence of leg volume assessment may limit the use of the measuring device and complicate study protocols when pharmaceutical or physical therapies are investigated for their ability to reduce leg edema over a certain time period.
