Since the pathogenesis of this condition is still unknown, diagnosis and treatment of this disease are often complicated by reliance on self-reported of the patient himself.
In studies showing suboptimal results with azithromycin, patients were often seronegative after treatment [ 16], raising the potential impact of sub-optimal therapy on seroconversion and further complicating reliance on a serology-based diagnosis [ 39].
Establishing effective recruitment strategies was further complicated by a reliance on primary care clinicians as the main source of referral into the scheme.
The situation is complicated by NorthPoint's reliance on big telecommunications companies for its connections to the fat pipes that are, in essence, the main conduits of Internet traffic.
But while the U.S. has committed to training and equipping more moderate Syrian fighters this year, its failure to do so sooner and softening position on Assad -- which will not sit well among moderates -- complicate any major reliance on them.
Its task is somewhat complicated by Broadway's growing reliance on big stars — the Hugh Jackmans, Jude Laws and Denzel Washingtons.
Many proposals designed to achieve this are complicated both by their sole reliance on public purchasing and the difficulties in pricing assets.
The regime's reliance on "mutual surveillance" complicated their moral burden, instilling feelings of shame and guilt that endured long after years of imprisonment and exile.
He said he was responding to a report on Monday by a UBS Warburg analyst who questioned Tenet's heavy reliance on revenue from special Medicare reimbursements awarded for complicated and expensive cases.
Mr. King outlined difficulties confronting policy makers, including a drop in the value of the euro, which posed problems for British exporters and complicated the task of moving the British economy away from its reliance on financial services and toward manufacturing.
Reliance on computer generated timestamps for correlating events is complicated by uncertainty as to clock skew and drift, environmental factors such as location and local time zone offsets, as well as human factors such as clock tampering.
