It appears that despite using SCID mice, the system was complicated by pathology resulting from an innate immune response, in the form of neutrophil infiltration, directed against the CHO cells.
The initiation and progression of atherosclerosis are complicated, multifaceted pathologies which remain incompletely understood.
Despite this view, about 40% of his patients without complicating organic pathology were reportedly returned to active service, about 40% to light duty or prolonged rest previous to duty and about 20% to base hospitals.
Little is known about pathogenesis of these complex neurological diseases and it is currently unclear whether these chronic diseases might be complicated by degenerative pathology.
Whatever mechanism is responsible for the distinct facial morphology of the exencephalic Neo/Null mice, the overall result suggests that understanding the etiology of CL/P in humans will be complicated if this pathology is also accompanied by a cranial neural tube closure defect.
However, studies of the direct and primary molecular sequelae of dystrophin deficiency in intact animals and tissues are complicated by secondary pathologies resulting from degenerative, regenerative, fibrotic and inflammatory changes.
The treatment of thoracic aortic pathology is complicated by the morbidity of the surgical procedure, and the comorbidities encountered in an elderly population.
When acute pancreatitis develops due to a synergistic effect with the condition of the patient after an esophagectomy, the pathology becomes complicated, leading to a requirement for long-term multidisciplinary care.
To date, few randomized controlled studies have shown improvements in clinical outcome [ 22] despite convincing evidence in basic science [ 23], but research has been complicated by variations in pathology [ 24], preparation [ 25, 26], and recruitment.
