We believe that future research should be pointed either at different targets when using mouse models for Fetal Alcohol Syndrome (e.g. more complicated behavioral paradigms, different hippocampal substructures, or other brain structures) or involve different animal models.
We believe that future research should be pointed either at different targets when using mouse models for FAS (e.g. more complicated behavioral paradigms, different hippocampal substructures, or other brain structures) or involve different animal models, including zebrafish [ 22] or guinea-pig [ 23].
Pharmacokinetic interactions have particular implications in HIV-coinfected and transplant populations, where drug drug interactions will complicate treatment paradigms, so that any use of BOC or TVR in transplant or HIV-coinfected populations of patients with HCV should be done with caution and under close clinical monitoring.
But my mother's choice, and the choice of those like her, complicates this simple paradigm.
The situation is complicated, and unraveling requires changed paradigms especially regarding the structure of the monomer-in-water system at surfactant concentrations below the CMC.
This developmental paradigm has been further complicated by studies which have demonstrated that alpha-smooth muscle isoactin is also expressed during early cardiac and skeletal muscle development in a variety of myofibroblast-like cells [ 34, 45- 48].
Indeed, scientific results are seldom straightforward, and the whole process of scientific progress is driven by debates and competing paradigms, complicating the task of influencing the policy-making realm.
In this backdrop, the definitional paradigm of the coping response becomes complicated when societal components and risk perception are introduced in the said paradigm (Schmidtlein et al. 2008; Lo 2013).
The process, of course, is complicated if you're presented with conflicting paradigms.
Comparison among models is further complicated by methodological differences in social testing paradigms used in different studies.
