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What makes Wolfram's dream interesting is the undeniable fact that simple rules can lead to some very complicated outcomes.
Thirty-eight episodes of neutropenic fever with complicated outcomes were identified from among a total of 192 episodes.
Subsequently, secondary analysis was conducted on the 63 total leukocyte genes whose dysregulation is known to predict complicated outcomes after severe trauma [ 8].
In this regard, complicated outcomes were defined as either ICU hospitalization longer than 14 days with evidence of ongoing organ dysfunction, or death [ 6, 15].
The primary potential weakness of this study is that it is difficult to conclude whether the failure of the PMN transcriptome to return to baseline in the aged is either the result of more frequent complicated outcomes or their cause.
Immunological monitoring could help to improve outcome in sepsis, by providing early detection of individuals at higher risk for developing complicated outcomes as well as relevant information for guiding treatment.
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The seeming alignment between public health and public safety risks and outcomes place a burden on assessment protocols to reflect both CJ risk and need factors, including health issues that complicate outcomes.
Even still, risk factors can often complicate outcomes.
Two patients had particularly complicate outcomes.
Of course that is not a bad result but it would complicate outcome analysis.
Moreover, well-intended established procedures such as fluid resuscitation may impair coagulation homeostasis, thus possibly complicating outcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com