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Patient outcomes, including causes of death other than CO-MSSA bacteraemia and breakdown of complicated infections, are listed in Table 2. Of the 46 patients with the primary outcome of complicated bacteraemia, seven (15.2%) were re-admitted for recurrent MSSA infection, whereas 33 (71.7%) had complicated infection.
The primary end point was complicated SAB (attributable mortality, complicated infection, embolic stroke, or recurrent S aureus infection during the 12-week follow-up period).
When a condition could be classified into several categories related to the same pathology, only the most severe was retained (severe infection > complicated infection > other infection > urinary infection; complicated diabetes > diabetes without complications).
Many patients develop uncomplicated resolving infections that respond to appropriate antimicrobial therapy while others develop persistent or complicated infection with metastatic foci (e.g. infective endocarditis (IE)), which may be fatal.
Sullivan, S. B. et al. Reduced vancomycin susceptibility of methicillin-susceptible Staphylococcus aureus: no significant impact on mortality but increase in complicated infection.
Patients were excluded if they had known or suspected complicated infection at the time of randomization.
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It is an appealing option for the treatment of these complicated infections.
For complicated infections, decreased susceptibility could compromise treatment with drugs from either antimicrobial class.
UTIs in adult males are considered complicated infections according to most clinical definitions [ 16- 18].
Daptomycin is licensed in adults for the management of Staphylococcus aureus methicillin-resistant infections, including bone and skin complicated infections.
Complicated infections and electrolyte disorders [ 4] may aggravate respiratory muscle weakness and lead to prolonged use of MV.
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