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Methods to estimate thermal contact resistance usually require temperature measurements taken inside the sample (test body) and complicated experimental arrangements.
Another problem is alignment of optical elements separated by 65 m within complicated experimental conditions connected with aperture limitations (down to 6 mm).
Finally, the advantage of the SSR-patchwork protocol over existing techniques in time and cost is illustrated in Fig. 4. The SSR-patchwork protocol presented here is simple, fast, inexpensive, does not require complicated experimental steps (Fig. 4), and is effective for both small and large genomes (Table 1).
Optimization of dampers design is a complex task usually associated with analysis of nonlinear contact problems and complicated experimental verification.
For instance, the accuracy of predictions is based on material parameters, which are obtained mostly from complicated experimental studies or from the literatures.
The authors have done extensive laboratory work to determine these two parameters and their laborious and complicated experimental program needs praise.
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However, existing literature on kappa receptor antagonists has used extensively JDTic and nor-BNI which exhibit long-lasting pharmacokinetic properties that complicate experimental design and interpretation of results.
Thus, we expected that some of the functional effects of clathrin removal may be abrogated by compensatory changes during this time period and that these would obscure or complicate experimental analysis.
Interference with metabolism can easily cause many side effects and is often lethal in central metabolic pathways, which further complicates experimental design and interpretation of results.
However, the presence of an additional index tag may complicate experimental procedures, decrease capture specificity, and result in a substantial proportion of reads with an inappropriate index tag [ 14, 15].
We did not track oestrus phase in female mice as this greatly complicates experimental design and introduces a female specific stressor (vaginal gavage for cytological examination of circulating ovarian hormones) that may well confound pain.
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