The diagnosis is complicated by difficulties obtaining ocular tissue, difficulties isolating the organisms from aqueous aspirates, tests that are neither sensitive nor specific, and the variability in clinical presentation [1].
Fluid balance concerns occur daily in critically ill patients, complicated by difficulties assessing intravascular volume.
Diagnosis of primary hepatic angiosarcoma is complicated by difficulties in the qualitative radiological assessment of these tumors.
Our efforts to crystallize the ACP KS complexes of fatty acid synthases have been complicated by difficulties in the purification of the crosslinked complex from the other proteins in the reaction.
Detailed measurements of the below ground structures of linear emergent macrophytes, in terms of their biomass and architecture, are complicated by difficulties associated with sampling in the highly saturated sediments that these morphotypes typically occupy.
Many studies have detected significant effects of changing the number of species in experimental treatments on productivity and other response variables, but interpretation of these results is complicated by difficulties in separating effects of number, identity and relative density of species.
The disparities are complicated by difficulties many rural dwellers face accessing medical care.
The cloning of palindromes is frequently complicated by difficulties associated with cloning inverted repeats [8], [9] and may require sequential steps to clone the respective arms of the palindrome [10].
"Darfur's national measles campaign is complicated by difficulties of ongoing conflict and poor access.
Any study of selection affecting indels is complicated by difficulties in determining the indel mutation rates.
