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Interactive effects between chemical and natural stressors as well as genetically determined variation in stress tolerance among individuals may complicate risk assessment and management of chemical pollutants in natural ecosystems.
Optimization models and related solution methods may be limited by the problem or computational complexity that may arise from numerous stakeholder influences and complicate risk constructs.
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This will further complicate risks for perception of aid personnel, the secure access of humanitarians to populations in need, and their access to assistance and medical care when needed.
There are no accurate models that predict the disease course and outcomes, which complicates risk assessment and counselling for individual patients, stratification of patients for trials, and timing of interventions.
Mr. Mudd replied that the company, in recruiting employees to manage its complicated risk policies and to devise the financial instruments that allowed it to finance such a large portion of the mortgage market, was competing for employees not with nonprofit groups but with well-paying for-profit companies and with Wall Street.
The possibility of measuring bacterial DNA load to predict outcome or evaluate therapeutics in bacterial diseases, especially those with high mortality, antimicrobial resistance, multiple and complicated risk factors, has been raised but never been fully explored [1], [2].
We tested this possibility by investigating bacterial loads in Acinetobacter baumannii bacteremia, a rapidly increasing nosocomial infection characterized by high mortality, drug resistance, multiple and complicated risk factors, all of which urged the need of good markers to evaluate therapeutics.
Previous studies have identified multiple and complicated risk factors for the high mortality of A. baumannii bacteremia [5], [6], [10] [15], but none has investigated the roles of bacterial load in the disease outcome.
Nonetheless, our findings that high and increased Oxa-51 DNA load can predict mortality in A. baumannii bacteremia support the notion that measuring bacterial DNA load could predict disease outcome or monitor therapeutic responses, and may have implications to our understanding of pathogenesis, particularly for those bacterial diseases with high mortality, multiple and complicated risk factors.
Previous accusations that insulin is atherogenic have since been dismissed, but they complicated risk assessments in a bygone era (37).
However, recent epidemiological studies have not been enough to elucidate complicated risk factors for FLD, despite the high prevalence and importance of the disease [ 4- 6].
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