Unfortunately, this generally provides very different and "unpredictable" chromatograms which can be difficult to interpret, thus complicating peak detection and peak tracking (i.e. matching peaks among all the chromatograms).
P NMR chemical shifts of phosphorus acids are sensitive to pH, and standards are often reported in highly acidic solutions complicating peak identification in our spectra.
Such shifts can complicate automatic peak assignment during data-handling.
(3) Moreover, there is an increase of the baseline drift and "negative peaks" at the beginning and medium part of the chromatogram analysis; these two issues could complicate the peaks integration and correct quantification.
In the present study, the HSQC spectra were considered to be highly appropriate for the differential analysis, because they provide both H and C chemical shift information but yield much less complicated cross peak patterns than HMBC due to the restriction to only one-bond H C correlations.
And the bad news is that everyone wants to see it at absolutely the same time.' " To complicate matters, the Peak is a moving target.
As one moves away, the field pattern can be complicated, with peaks and valleys in field intensity with increasing distance from the antenna.
In this case the LLOQ was limited by the specific lineshape of the H NMR signal that differs notably from the standard Lorentzian peak shape, thereby complicating the automatic peak recognition and the signal position.
Furthermore, so-called escape peaks, scatter peaks, peaks originating from the instrument as well as overlapping peaks can complicate interpretation, which is especially challenging when investigating non-homogeneous multilayer materials such as paintings.
In effect, the BOC p,1) ACFs with p > > 1, in contrast to that of BOC 1,1) modulation, produce several side peaks which complicate the DLL locking operation.
