To account for the occurrence of the gigantic M9 earthquake on the interplate megathrust where M7-class events repeatedly occur, simulation models incorporating complicated interactions of asperities have been developed based on the rate- and state-dependent friction (RSF) law (Hori and Miyazaki2011; Kato and Yoshida2011; Shibazaki et al.2011; Mitsui et al.2012; Noda and Lapusta2013).
Whilst a SNOM approach would be eleborate and come with many of the pitfalls still associated with near-field scanning microscopy; the SNOM-superlens setup would have two important advantages over the SNOM only setup: (1) The complicated interactions of the sample with the dynamic SNOM probe [14] do not apply and are replaced by interactions of the sample with the static superlens.
Such applications involve complicated interactions of random error, selection bias, measurement error, and other sources of uncertainty that compound in mathematically complicated ways.
The links between cancer and diet can be initiated early in life, commencing from embryogenesis and fetal development, through early childhood when complicated interactions of multiple environmental factors, including diet, influence the developmental trajectories and physiology resulting in subsequent increase in cancer risk later in life (Frankel et al. 1998).
Such novel phenomenon was considered as the result of complicate interaction among the two polyelectrolytes and solvent.
All displayed complicated interaction patterns, two of which were found to be more intriguing.
Many of these involved several whales and were complicated interactions, but eight of them were unambiguous quarrels between a father and a mother.
In recent years, one such model has emerged providing a means to scientifically dissect complicated interactions at all levels of biological organization.
Therefore, a more comprehensive model which is not limited to PPIs should be constructed to model the complicated interactions involved in the mechanism of action for drug combination.
Incorporating as many of these complicated interactions into a model is essential for identifying potential drug targets, as cells are remarkably robust and have built-in fault tolerance systems that may not be evident from examination of static network or interaction diagrams [ 56, 62, 63].
