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Dr. Thomas Insel, director of the National Institute of Mental Health, said the new landscape might complicate development of genetic diagnostics for schizophrenia but not necessarily of therapies.
Last week he unveiled an ambitious initiative to maintain the Meadowlands as a center for professional sports in an attempt to make some of the professional teams there think twice before leaving and at the same time complicate development of the planned Xanadu complex.
These observations illustrate the diversity in the architectures of the ATP-binding pocket present within the APH family of enzymes, which will undoubtedly complicate development of broad-spectrum inhibitors.
Both conditions may reinforce each other, may complicate development, and may influence functioning [ 35].
Antti Poso used virtual docking approaches to model sirtuin substrate interactions and described structural features of this interaction that complicate development of novel sirtuin modulators.
These considerations complicate development of reliable quantitative methods for assessment of differences in the distribution of connexin label between normal and AF samples.
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With planners warning that the law will not give small towns enough time to review complicated development projects, the New Jersey League of Municipalities has advised towns to automatically deny zoning permits if it looks like they will not be able to meet the deadline.
These results indicate that microstructural architecture needs to be accounted for in an accurate continuum model, thus complicating development of such a model.
A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs.
Cross-talk and feed-back loops within the pathways make up a complex signaling network complicating development of targeted treatments and the establishment of reliable biomarkers [ 1].
Numerical methods are tools for approximating solutions to problems that may have complicated developments or cannot be solved analytically.
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