Background variance in such canine trials also models common challenges involved in human clinical trials, including recruitment, randomization, participant compliance with trial design, and the potential for other confounding factors, such as other health problems or use of other medications.
Compliance with trial medication will be assessed by capsule count.
Every attempt (within ethical constraints) will be made to obtain outcome data, regardless of subjects' compliance with trial protocols.
The procedure for obtaining outcome data will be followed for all participants, regardless of compliance with trial protocols.
Participants were interviewed at monthly intervals to check for possible side effects, illnesses, and promote compliance with trial medication.
Every attempt (within ethical constraints) will be made to obtain outcome data, regardless of subject's compliance with trial protocols.
Results might not be representative of the uro-nephrological field as a whole and reported figures may overestimate compliance with trial registration.
Our results might, therefore, overestimate compliance with trial registration and be, accordingly, not representative of the uro-nephrological field as a whole.
In a short questionnaire, women answer questions on compliance to trial medication, the use of vitamin supplements and the use of alcohol, tobacco and drugs.
Attention will also be given to compliance, as trial medication is one capsule size larger than regular flucloxacillin, possibly leading to decreased compliance and thus bias towards non-inferiority.
By studying developments in the number of registered clinical trials, differences in those developments between regions and countries, and differences in the events that have driven registration, we also provide insight into the measures that are needed to achieve improved compliance with trial registration.
