For this study the study team developed the questionnaires in English language using standard questions to ascertain the information on diarrhea, its treatment and compliance of interventions.
Specifically, the poor reach and compliance of the intervention resulted in a small proportion of the target population using the intervention as intended.
28 In a randomised controlled trial (RCT) conducted by the Oslo Sports Trauma and Research Center OSTRCC), the compliance of the intervention group was too poor for a statistically significant effect of the programme.
The fact that we did not find this effect after 12 month suggests that the intensity or the compliance of the intervention was not strong enough with respect to physical activity and perhaps further measures should be taken to ensure progression and compliance in the physical training.
For the pharmacological interventions, we will record the drug category (eg, AEDs), chemical name of the drug, dose, way of administration (eg, oral, muscular injection), the whole treatment period and the compliance of the interventions.
Although not all included trials examined the acceptability and compliance of the interventions, low compliance and acceptability can represent potential limitations of the included trials.
The compliance of the interventions was assessed by observing the empty blisters of zinc tablets and sachets of ORS and water purification powder.
In an editorial, to this review, we highlighted that there remains a paucity of information regarding intensity, duration and compliance of the interventions, all of which could account for the lack of efficacy, as well minimal evidence for any effect of the intervention on the targeted behaviours.
The use of such different definitions may markedly affect the assessment of compliance to interventions, making comparison between studies difficult.
Outcome data from the two groups will be compared using an intention to treat analysis with all patients being analysed in the group to which they were originally randomly assigned even though they are lost to follow-up or non-compliance of the intervention or any other deviation from the protocol [ 56].
