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Ang1 −/− animals display a marked reduction in the complexity of vessel branching, fewer endothelial cells and reduced endothelium-matrix contacts (Suri et al., 1996).
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Due to the increase of complexity of vessels and the operations they perform, however, more applications of system identification are needed to obtain to models valid across different VOCs.
Observation of the in vivo vasculature is difficult due to the complexities of vessel geometry, limited visualization capability, as well as variability and complexity inherent to biologic systems.
Another advantage of this new system is that there will be no need to include the accessories employed in traditional tanks, such as: fins, perforated tube in the tank center and a cooling external jacket, which would increase the complexity of the vessel design.
Overall, the nodal difference tends to increase with the increasing complexity of the vessel model, reaching its maximum in the case of the model of dissected aorta.
The underlying mechanism that causes the development of growth instability is not fully elucidated, presumably due to the considerable complexity of the vessel growth control.
In Figure 4B and C (middle panels), the Pkd1cond/−, Meox2-Cre+ placenta was similar to wild type, with respect to the density and complexity of placental vessels.
Fractal analysis has been used in many branches of medicine to characterize the geometric complexity of blood vessels, including those in the eyes (9, 12, 14).
Data are expressed as mean fractal dimension (mean-D), a parameter that reflects complexity of the retinal vessel branching.
The available data obtained in adult subjects [ 21] or children [ 31] are consistent with our findings, which show a reduced complexity of the retinal vessel branching.
Fractal analysis is a method to quantify the geometric pattern and complexity of the retinal vessels.
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