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In the concluding section, we discuss potential constraints on clinical trials using quantitative imaging, including complexity of trial conduct, impact on subject recruitment, incremental costs and institutional barriers.
However, with increasing complexity of trial data, appropriate sample size formulas are often missing.
It is essential that future research recognises the complexity of trial design, implementation, and evaluation.
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Until recently, there has been little consensus on the effectiveness of LSM, stemming partly from the complexity of trialling this type of environmental intervention, meaning that relatively few good studies exist.
Given the complexities of trial communication when a child's life is threatened, the therapeutic misconception does not necessarily reflect a straightforward failure of the researcher to adequately explain the research methodology or of the parent to understand it.
Goldacre does a good job of explaining these highly technical processes, and those unfamiliar with the complexities of trials will surely be appalled that so many trials are unreliable.
In this way, the increasing demands of regulators that have led to increasing complexity of clinical trial programmes are highly relevant to the increase in clinical trial periods we have observed.
Under it, the prosecution in a serious fraud case can apply for a non-jury trial where the judge is satisfied that "the length or complexity of the trial is likely to make it so burdensome upon the jury that the interests of justice so require".
The trial was designed to minimise bias [ 19] but the complexity of the trial meant it could not be fully blinded, as recruiters knew practice allocations in some cases.
Our results show that these difficulties might have been linked to the overall complexity of the trial itself and how doctors explained the stratified medicine aspect of the trial.
[Excerpts, Page A16.] Against the vast complexity of a trial expected to last for two years, she suggested that what drove Mr. Milosevic was elemental.
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CEO of Professional Science Editing for Scientists @ prosciediting.com