Efforts to develop vaccines against these pathogens have been prevented by the difficulty of cultivation of parasites in the laboratory, the complexity of their multicellular organization and many species have been developing impressive antigenic variability.
Hence, in terms of the complexity of their subcellular organization, there is a great divide separating the simplest eukaryotic cell and the most complex cells among prokaryotes.
Earlier studies shed light on the complexity of their internal organization [ 5], while most recently another feature of these organelles has attracted considerable interest, their highly dynamic behavior [ 6].
However, the imaging of trabecular bone is delicate because of the accessibility of the sites of bone measurement, the small size of the trabecular bone's structure (estimated at a few hundred micrometers), and the complexity of their three-dimensional organization.
This technique allows for the survey of the entire transcriptome in a very high-throughput and quantitative manner, making it possible to identify exons and introns, map their boundaries and the 5′ and 3′ ends of genes, and understand the complexity of genome organization and activity comprehensively.
The development of guilds and confraternities reflected the growing complexity of economic organization.
"I think he didn't understand the complexity of the organization in terms of its constituency," said Bill Stapleton, chairman of the U.S.O.C.'s athletes advisory council.
It can also be seen as the consequence of the growth of multinational corporations; this, too, is the result of the increase in scale and complexity of industrial organization, a clear tendency from the very start.
